RADIESSE® Volumizing Filler is made of calcium hydroxylapatite. Therefore, it is different from most of the other fillers which are made of hyaluronic acid. It is the only filler to both immediately replenish lost volume and stimulate the production of your own natural collagen. Radiesse is truly unique in its ability to act as a scaffold under the skin, providing lift and stimulating the production of your own natural collagen. It is a perfect filler if you have significant volume loss and are looking for immediate volumizing with long-term results. In fact, when filled to optimal correction, you can expect Radiesse to last up to a year. And over time, as the Radiesse helps to stimulate your own collagen, you will notice that the Radiesse lasts longer and longer between injections.