Do you know anyone who takes spironolactone? If you’re a woman in your mid-20s, chances are you probably do. This medication is used off-label to treat hormonal acne in women, a skin condition 50.9% of women in their 20s and 25% of women in their 40s struggle with—plus, research shows this kind of “adult acne” can persist even after the age of 501. Men can experience hormonal acne as well, but it’s much more common in women, especially in adulthood.